Endocrine Abstracts

Ipilimumab is an anti-CTLA-4 monoclonal antibody licensed for metastatic melanoma.A 70-year-old female with metastatic malignant melanoma presented with anorexia, malaise and confusion two weeks after her fourth dose of Ipilimumab. She had a low serum sodium of 124 pmol/L on proton pump inhibitor and selective serotonin reuptake inhibitors, which were stopped and she was fluid restricted to 1.5 litres/day. Her urinary sodium wa...

Ipilimumab is an anti-CTLA-4 monoclonal antibody licensed for metastatic melanoma.A 70-year-old female with metastatic malignant melanoma presented with anorexia, malaise and confusion two weeks after her fourth dose of Ipilimumab. She had a low serum sodium of 124 pmol/L on proton pump inhibitor and selective serotonin reuptake inhibitors, which were stopped and she was fluid restricted to 1.5 litres/day. Her urinary sodium wa...

Rationale: The Aldosterone:Renin ratio (ARR) is commonly used for patients fulfilling screening criteria for primary hyperaldosteronism (PA), followed by confirmatory testing. Reference intervals for interpretation of the ARR vary in accordance with local population and assay 1. While ARR provides high sensitivity for PA, this is compromised by low specificity, further compounded by medication interference. However, additional variables may improve the specificity of ARR as a ...